Reduced Expression of SFRP1 is Associated with Poor Prognosis and Promotes Cell Proliferation in Breast Cancer: An Integrated Bioinformatics Approach

Breast carcinoma is the most frequent form of malignancy in women globally. Exploration breast cancer genome tiled way for validation novel biomarkers and to explore various mechanisms involved progression carcinogenesis. The purpose research find an identification potential gene linked (BC) prognosis. Three datasets (GSE71053, GSE61724, GSE36295) were downloaded from Gene Expression Omnibus (GEO) database. An integrated analysis several expression profile was used differentially expressed genes (DEGs) BC normal tissue samples. Protein–protein interaction (PPI) network verify hub associated with pathogenesis prognosis BC. functional enrichment pathway performed by FunRich cBioPortal. pattern assessed using COSMIC, GEPIA2, BC-GenExMiner. results revealed that among genes, Secreted Frizzled-related protein 1 (SFRP1) a negative regulator Wnt cancer. Loss SFRP1 may result abnormal cellular proliferation, migration, invasion, which trigger cells, leading disease, poor prognosis, therapy resistance. Lastly, Kaplan–Meier plotter online database demonstrated levels related lower survival. findings this would provide some directive significance further investigating diagnostic prognostic biomarker facilitate molecular targeting cancer; be effective as early